The 2010 Pagani Zonda F has been spied in Australia.  There is not much to distinguish it from the regular Zonda F. It gets an all new front clip and the rear quarter panels have been re-sculpted to allow for significantly increased airflow. If you look closely there is a totally new air scoop at the middle of the engine cover.

However the biggest change expected is in the engine compartment. Instead of using the 7.3L Mercedes AMG V8 found in the current Zonda, there are rumors of the 5.4L supercharged V8 from the McLaren SLR 722 or the bi-turbo V12 from the recently launched Mercedes SL65 AMG Black series giving a good amount of power to the new Zonda F.